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International Journal of Pharmacy and Pharmaceutical Science

Vol. 3, Issue 1, Part A (2021)

Comparing aspirin, enoxaparin, and rivaroxaban post primary total knee replacement: A prospective study from Saudi Arabia

Author(s):

Mariam Ahmad Alameri, Dr. Syed Azhar bin Syed Sulaiman, Dr. Abdullah Moh’d Talaat Ashour and Dr. Ma’ad Faisal Al-Saati

Abstract:

Background: Patients undergoing major orthopedic surgery are at significantly high risk for venous thromboembolism (VTE), and therefore the routine use of thromboprophylaxis has been standard-of-care for several years. The aim of this study is to compare the clinical outcomes for aspirin, enoxaparin, and rivaroxaban post primary total knee replacement surgery. 
Method: This is a prospective observational study that is done in two medical centers in Saudi Arabia. A prospective data collection sheet was used to follow up each patient for 35 days post-surgery. 
Results: In this study, 242 patients were included with a response rate of 87.86% (242/276), according to the type of Extended VTE Prophylaxis medications patients were divided on 3 groups; Enoxaparin 85/242 (35.1 %), Rivaroxaban 128/242 (52.9 %), Aspirin 29/242 (12.0 %). 
Conclusion: In this study, rivaroxaban has the worst profile, in both having the highest number of DVT cases, as well as 2 minor bleeding cases. Aspirin group patients have the best profile in terms of complications and recovery measures post-surgery. 

Pages: 31-36  |  53 Views  14 Downloads

How to cite this article:
Mariam Ahmad Alameri, Dr. Syed Azhar bin Syed Sulaiman, Dr. Abdullah Moh’d Talaat Ashour and Dr. Ma’ad Faisal Al-Saati. Comparing aspirin, enoxaparin, and rivaroxaban post primary total knee replacement: A prospective study from Saudi Arabia. Int. J. Pharm. Pharm. Sci. 2021;3(1):31-36. DOI: 10.33545/26647222.2021.v3.i1a.66