M Nikhila Devi, M Bhargavi, M Meghana, M Siva Sai Durga Prasad, M Sai Vishnu, A Lakshmana Rao
The present work was aimed to enhancement of solubility of Ambrisentan by using solid dispersion technique by solvent evaporation technique. Ambrisentan is a class II drug and hence it is formulated by using solid dispersion technique to increase solubility of drug with the aid of β-cyclodextrin. Solid dispersion was prepared by combining of drug and carrier. The physical mixtures were prepared by solvent evaporation technique accordingly with the composition given in table. The ingredients like drug and carrier were accurately weighed (in different ratios 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7) and mixed in porcelain dish with a stirrer for 10 min to get uniform mix by using ethanol. The above substance was dried. These are sieved to obtain granules by using sieve no.20. The blended powder was filled into capsules. The observed results reveals that carrier have significant effect on drug release up to 1 hr after successful development of solid dispersion containing Ambrisentan and β-cyclodextrin carrier in different ratios (1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7).
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