Vol. 4, Issue 1, Part A (2022)

Mouth dissolving film is a Noval dosage form which disintegrates in mouth within seconds with rapid onset of action and most convenient for oral route of administration. Patient compliance will be impediment for bitter drugs become unpleasant unless taste masked. Desloratadine is an antihistaminic and often prescribed for elderly and children hence the objective of this study is to develop a pleasant, patient friendly mouth dissolving film with superior patient compliance. Taste masking of Desloratadine was done with resin indion-204 and indion-234 complexation. The taste masked complex was formulated as mouth dissolving film Superior product performance characteristics were observed in terms of Disintegration time, vitro drug release all remained stable during the stability trial a laboratory scale up was performed to ensure the feasibility of commercial manufacturing.