Surjeet Kumar Shahi, Dr. G Pavan Kumar and Gyan Singh
Cancer can be defined as a disease in which a group of abnormal cells grow uncontrollably by disregarding the normal rules of cell division. Cancers arise approximately in one among every three individuals. DNA mutations arise normally at a frequency of 1 in every 20 million per gene per cell division. The average number of cells formed in any individual during an average lifetime is 1016 (10 million cells being replaced every second!). Risk of cancers are increased by infectious agents including viruses [Hepatitis B virus (HBV1), Human Papillomavirus (HPV), Human Immunodeficiency Virus(HIV)-increase risk of Nasopharyngeal, Cervical carcinomas and Kaposi’s Sarcoma] and bacteria such as Helicobacter pylori (Stomach cancers). Candidate molecules were docked for anticancer activity against the modeled protein target mTOR using drug design software (Maestro 9.1). Twenty five scaffolds were screened with high docking score against mTOR inhibitor. These compounds also passed Lipinski’s rule. The scaffold containing quinoline nucleus was selected on the basis of synthetic feasibility.
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