Vol. 6, Issue 1, Part B (2024)

Using two distinct natural binders aliv and basil a laboratory study was conducted to assess the impact of binder on the physico-chemical characteristics and quality of paracetamol tablets made via the wet granulation method. Tablets account for more than 70% of drug dosage forms due to their superior dose accuracy, stability, affordability, large-scale manufacturing, variety of drug release mechanisms, simplicity of transportation, and patient compliance. Binder is one of the primary components combined with the medication during tablet dosage form production, and it is crucial to the tablets' intended quality ^[14]. 
The aim of this study was to evaluate the binder effects of living powder and basil, which are used as food and pharmaceutical excipients due to their affordability, biocompatibility, and biodegradability. The physical characteristics of the tablets (weight, hardness, thickness, friability, content uniformity, disintegration, and dissolution) and granules (bulk density, tapped density, Carr's index, flow rate, and angle of repose) were evaluated [11]. All pre-compression and post-compression parameter results fell within an acceptable pharmacopoeia range. In dose form, aliv and basil work incredibly well as binders ^[10].