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International Journal of Pharmacy and Pharmaceutical Science

Vol. 6, Issue 2, Part A (2024)

Green synthesis of marine sponge silver nanoparticles and its antioxidant, cytotoxic activity

Author(s):

Bhagyasree S and Sunbee Prakash

Abstract:

Marine sponges have emerged as a rich source of bioactive compounds with potent anti-cancer activities. This study explores the anti-cancer potential of marine sponge-assisted silver nanoparticles (AgNPs) through comprehensive collection, identification, synthesis, and evaluation processes. Marine sponges were collected from the Rameswaram district in Tamil Nadu, India, and identified using genomic sequencing techniques. Ethanolic extracts from these sponges facilitated the green synthesis of AgNPs, which were characterized by particle size and zeta potential analysis. The synthesized AgNPs demonstrated significant antioxidant activity in DPPH radical scavenging assays, indicating their ability to neutralize free radicals effectively. Cytotoxicity assays revealed a dose-dependent inhibition of L6 cell proliferation, with high concentrations showing substantial biological activity. Further, acridine orange/ethidium bromide staining confirmed the induction of apoptosis in L6 cells treated with marine sponge-assisted AgNPs. These findings suggest that marine sponge-derived AgNPs possess promising therapeutic potential, particularly in developing targeted anti-cancer therapies and antioxidant treatments. The study underscores the need for further research into the molecular mechanisms of these nanoparticles and their optimization for specific biomedical applications.

Pages: 01-07  |  67 Views  25 Downloads


International Journal of Pharmacy and Pharmaceutical Science
How to cite this article:
Bhagyasree S and Sunbee Prakash. Green synthesis of marine sponge silver nanoparticles and its antioxidant, cytotoxic activity. Int. J. Pharm. Pharm. Sci. 2024;6(2):01-07. DOI: 10.33545/26647222.2024.v6.i2a.116