Vol. 6, Issue 2, Part A (2024)

A simple, economical, accurate, precise and less time-consuming Spectrophotometric first order derivative method for simultaneous estimation of Rosuvastatin and Fimasartan in synthetic mixture. In this method Rosuvastatin and Fimasartan are exhibits maximum absorbance (λ max) at 263 nm and 246 nm with methanol as the solvent. The method was validated as per the ICHQ2R1 guidelines. Drugs followed the linearity in the concentration range of 30-150 μg/mL and 5-30 μg/Ml for Rosuvastatin and Fimasartan respectively. The validity of the proposed method was assessed by applying the standard addition technique where the % recovery of the added standard was found to be 99.79 and 98.96 for Rosuvastatin and Fimasartan. The proposed method is recommended for routine analysis of ROS and FIM in synthetic mixture in regular quality control testing laboratories.