Vol. 6, Issue 2, Part A (2024)

Aim & Objective: The main aim of the study was to characterize 5 commercial Abhrak Bhasma 100puti preparations from 5 different manufacturers by using modern scientific techniques and to study their bioavailability in Wistar rat.
Materials and Methods: Abhrak Bhasma (AB) Shataputi was characterize by X-ray diffraction (XRD), Scanning electron microscope (SEM), Energy Dispersive X-ray analysis (EDAX), Nanoparticle tracking analyzer (NTA), inductively coupled plasma optical emission spectroscopy (ICP-OES). Bioavailability of Abhrak Bhasma 100 puti was studies using non compartmental rat model with daily dose of 11.25 mg/kg according to their body weight.
Results: The chemical phase and particle size was significantly different for all 5 AB preparations. Bioavailability study confirms difference in various pharmacokinetic parameters such as Cmax, Tmax, half-life (t 1/2), AUC etc. The maximum absorption (Cmax) was observed in sample A compared with other samples. 
Conclusion: The morphology as well as chemical phase of the five Abhrak Bhasma studied were different from each other, which might be responsible for different pharmacokinetic profiles in Wistar rats.