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International Journal of Pharmacy and Pharmaceutical Science

Vol. 6, Issue 2, Part B (2024)

Microwave assisted synthesis: An eco-friendly green chemistry approach of drug synthesis

Author(s):

Amitesh Chakraborty, Santanu Giri and Tushar Adhikari

Abstract:

One of the main disadvantages of Pharmaceutical Industries utilizing conventional method of Drug Synthesis is utilization of large amount of energy and producing multiple by-products. Modern approaches of synthetic chemistry focus on minimizing the utilization of the energy and reducing Carbon foot-print which in turn reduces the environmental burden. This is technically called Green Synthesis. There are multiple principles of Green Chemistry which streamlines the synthesis process to emphasize sustainability. Microwave based synthesis, flow reactors, ultrasonic wave assisted synthesis are among three major pillars of Pharmaceutical Green Chemistry. This chapter focusses on Microwave based synthesis as a major approach to reduce the carbon footprints in Pharmaceutical Industries. The reduction in energy consumption is mainly due to three major principles, namely dipolar polarization, ionic conduction and dielectric loss. This results in rapid heating by synthetic microwave ovens. In-spite of all these advantages, close monitoring of the synthesis is often practicable because local hot and cold spot formation leads to explosion of volatile solvents. Multiple drug moieties like quinolines, paracetamol, aspirin, dihydropyridines can be synthesized by this method in Pharmaceutical Industries.

Pages: 149-156  |  272 Views  103 Downloads


International Journal of Pharmacy and Pharmaceutical Science
How to cite this article:
Amitesh Chakraborty, Santanu Giri and Tushar Adhikari. Microwave assisted synthesis: An eco-friendly green chemistry approach of drug synthesis. Int. J. Pharm. Pharm. Sci. 2024;6(2):149-156. DOI: 10.33545/26647222.2024.v6.i2b.135