Ujala Gaur, Ashok Baghel and Dinesh Sharma
The objective of the present study was to formulate and evaluate novel mouth dissolving drug delivery system for bitter pharmaceutical. In this study, novel mouth dissolving taste masked formulations of Candesartan Cilexetil viz. mouth dissolving tablets with adequate mechanical strength using a mouth melting binder was prepared, optimized and evaluated for various in-vitro and in-vivo parameters. The formulated tablets, which can disintegrate or dissolve rapidly once placed into the oral cavity. The tablet is the most widely used dosage form because of its convenience in terms of self-administration, compactness and ease in manufacturing. However, geriatric and pediatric patients experience difficulty in swallowing conventional tablets, which leads to poor patient compliance. To overcome this weakness, we have developed innovative drug delivery system known as “melt in mouth” or “mouth dissolving tablet”. These are novel type of tablets that dissolves in saliva. There characteristics advantages such as administration without water, anywhere, anytime lead to their suitability to geriatric and pediatric patients. They are also suitable for the mentally ill, the bedridden and patient who do not have easy access to water. The benefit in terms of patient compliance, rapid onset of action, increased bio-availability and good stability make these tablets popular as a dosage form for the treatment of psychoses. In last few decades novel drug delivery systems have been developed to deliver antipsychotic drugs into the body in order to maintain rapid and constant drug level in the blood, to reduce the frequency of administration and to avoid excess drug loading in the body. Candesartan Cilexetil is a new antihypertensive recently marketed in a number of countries. Its main advantage over other atypical and typical drugs is its low propensity for causing weight gain. Candesartan Cilexetil is an oral and injectable drug that is used for treating hypertension. Candesartan Cilexetil activity is primarily due to the parent drug.
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