Vol. 7, Issue 1, Part D (2025)

Phenylhydrazine was used in condensation processes to create 4-aminobenzenesulfonamide derivatives. In order to produce new sulfonamide-based molecules with possible biological activity, the synthesis was conducted under carefully monitored circumstances. The amino group of 4-aminobenzenesulphonamide combines with phenylhydrazine in this nucleophilic substitution process to produce a triazene-linked sulphonamide product. The suggested chemical structures were confirmed by characterising the synthesised compounds using a variety of spectroscopic techniques, such as mass spectrometry, nuclear magnetic resonance (¹H NMR and ¹³C NMR), and Fourier Transform Infrared Spectroscopy (FT-IR). Using the disc diffusion method, the derivatives' antibacterial activity was assessed against a panel of strains of both bacteria that are both Gram-positive and Gram-negative, in addition to fungi. Significant antibacterial activity was shown by a number of derivatives, some of which had effects that were on par with or better than those of conventional antibiotics. According to these results, adding phenylhydrazine moieties to sulfonamide frameworks increases their antibacterial effectiveness and presents a viable path for the creation of novel medicinal medicines.