Vol. 7, Issue 2, Part A (2025)

Fungal infections, particularly those caused by Candida albicans (ATCC 10231), pose significant challenges due to increasing resistance and the adverse effects of existing treatments. This study investigates the synthesis and characterization of novel naphthalene hydrazone derivatives as potential squalene epoxidase inhibitors with enhanced antifungal activity. The derivative were synthesized, and their progress was monitored using thin layer chromatography (TLC). The compounds were characterized by determining their melting points and using various spectroscopic techniques, including Infrared (IR) spectroscopy nuclear magnetic resonance (NMR) spectroscopy. The antifungal efficacy of compounds was evaluated specifically against Candida albicans (ATCC 10231), with Napthalene hydrazone derivative showing superior activity compared to standard antifungal agents naftifine and nystatin. This research lays a promising foundation for the development of novel antifungal therapies, addressing the urgent need for more effective treatments with fewer side effects.