Vol. 7, Issue 2, Part G (2025)

Mucoadhesive drug delivery system interact with the mucus layer covering the mucosal epithelial surface, & mucin molecules that increase the residence time of the dosage form at the site of the absorption. Hence mucoadhesive drugs rapidly absorbed in mucus layer that increases bioavailability due to its considerable surface area. It was very critical concept to prepare mucoadhesive patches of Clofarabine which is used to treats acute lymphoblastic leukemia in pediatric and adult people with having a common side effect of Capillary leak syndrome (CLS) but this side effect along with other side effects minimizes by preparing Mucoadhesive buccal patches. We had prepared the mucoadhesive buccal patches by Solvent casting method using different concentrations of hydrophilic Polymers. Solubility of Clofarabine increases thrice by using beta-cyclodextrin for the formation of inclusion complexes. Using lower concentration of sodium alginate and higher concentration of cross povidone is used to release the drug from the buccal patches comparing to the concentration of HPMC and CMC. Maximum In vitro drug release 94% over a period of 8 h was observed by using higher concentration of Cross povidone for the preparation of a Mucoadhesive buccal patches. The use of hydrophilic polymers in the prepared Clofarabine buccal patches was able to substantially enhance the percentage of drug released from the patches, thereby increasing bioavailability.