Vol. 7, Issue 2, Part H (2025)

The evolution of bioanalytical sample preparation techniques has advanced to meet increasing demands for higher sensitivity, accuracy, and rapid analysis of complex biological matrices. Biological fluids often contain analytes at extremely low concentrations, necessitating efficient preconcentration approaches to minimize matrix effects. This review highlights modern, miniaturized, and green sample preparation technologies that enhance analytical speed, selectivity, and sensitivity. Significant progress in sorbent-based and microextraction methods is discussed, along with their applications in toxicology, clinical diagnostics, and pharmaceutical research.