Vol. 7, Issue 2, Part H (2025)

Herbal drugs have served as valuable therapeutic sources for centuries. However, their clinical potential is often limited by poor solubility, instability, and low bioavailability. Among modern approaches, phytosomes represent a remarkable breakthrough, improving the bioavailability of polyphenolic compounds by forming stable complexes with phospholipids. This technology enhances absorption, increases stability, and prolongs therapeutic efficacy compared to conventional herbal extracts.
The current review focuses on the phytosome approach, particularly with Camellia sinensis (Green Tea), a plant rich in catechins such as Epigallocatechin gallate (EGCG), known for its strong antioxidant, anti-inflammatory, and photoprotective properties. Despite its remarkable pharmacological potential, EGCG exhibits low oral bioavailability due to its hydrophilicity and rapid metabolism. Formulating green tea extract into phytosomes provides a promising solution by improving dermal penetration, chemical stability, and controlled release when incorporated into a topical gel base. Such formulations enhance catechin stability and skin compatibility, ensuring prolonged therapeutic action through sustained release.
Phytosomal preparations show enhanced antioxidant, anti-aging, and photoprotective activities, making them an ideal candidate for dermatological and cosmetic use. It further discusses the formulation strategies, evaluation parameters, and the advantages of green tea phytosomes over conventional herbal dosage forms. Additionally, it highlights the challenges related to large-scale manufacture and regulatory approval.
Overall, phytosome-based delivery offers a scientifically validated platform to bridge ancient herbal knowledge with advanced pharmaceutical technology, enabling safer and more effective therapeutic outcomes.