Vol. 7, Issue 2, Part I (2025)

The traditional South Indian polyherbal decoction comprising Cinnamomum verum (cinnamon), Piper nigrum (black pepper), Allium sativum (garlic), shallots, Syzygium aromaticum (cloves), Elettaria cardamomum (cardamom), Ocimum sanctum (tulsi), has long been employed in household and folk medicine for the management of fever and associated symptoms. This review consolidates ethnopharmacological evidence, phytochemical constituents, and the mechanistic basis underlying the antipyretic, anti-inflammatory, immunomodulatory, and antimicrobial actions of the individual plant components and the synergistic potential of the polyherbal blend. Key bioactive including cinnamaldehyde, piperine, allicin, eugenol, terpenoids, flavonoids, and saponins are highlighted for their influence on prostaglandin synthesis, cytokine regulation, oxidative stress modulation, and pathogenic inhibition. In addition, the review explores modern formulation possibilities such as ready-to-use decoctions, standardized extracts, nanoformulations, instant granules, and stable dosage forms aimed at enhancing patient compliance, stability, and therapeutic efficacy. By bridging traditional knowledge with contemporary scientific insights, this review underscores the potential of the polyherbal decoction as a promising phytotherapeutic candidate for fever management and supports future clinical validation and formulation development.